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Title: Detection of Angiogenic Growth Factor by Microcantilever Biosensors
Authors: Castagna, Riccardo
Supervisor/Tutor: Gasparini, Paolo
Ricciardi, Carlo
Co-supervisor: Bussolino, Federico
Issue Date: 28-Apr-2011
Publisher: Universit√† degli studi di Trieste
Abstract: To reach new and relevant insights in biomolecular sciences, new tools for fine and precise measurement are needed. Nowadays advances in the field of micro-electro-mechanical systems (MEMS) offer unique opportunities in the design of ultrasensitive analytical devices to support the molecular sensing investigations. Among them Microcantilever (MC) biosensors are label-free platforms that combine a biologically sensitive with a physical transducer in order to selectively and quantitatively detect the presence of specific compounds in a given external environment. Since they can be operated either as nanomechanical resonator or as surface stress sensor, MCs - activated with DNA probes or antibodies for molecular recognition - enable the measurement of mass with extraordinary sensitivity. In particular, the development of mass detector biosensor based on MC systems would permit to shift from qualitative data to quantitative measurements of key molecules involved in physiological processes. This can lead crucial informations to characterize complex mechanisms such as angiogenesis and tumor progression and to the quantification of small amounts of cancer markers, such as Angiopoietin-1 (ANG-1), and their modulation during the early stages of tumor development.
PhD cycle: XXIII Ciclo
Description: 2009/2010
Keywords: biosensor
label free detection
cancer marker
Main language of document: it
Type: Tesi di dottorato
Doctoral Thesis
Scientific-educational field: BIO/11 BIOLOGIA MOLECOLARE
NBN: urn:nbn:it:units-9060
Appears in Collections:Scienze biologiche

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