Bilitranslocase and anthocyanins role in the gastrointestinal tract
Bilitranslocase (BTL) is a organic anion transporter expressed in liver and in several extra-hepatic tissues. This membrane protein transports different substrates as pyrrolic molecules, nucleotides, flavonoids. Anthocyanins, one of the most represented flavonoids class are known to have antioxidant activity. They act as anti-inflammatory, anti-cancer and anti-proliferative molecules by interfering with different intracellular pathways. Some chronic colon diseases results in an increase in the pro-inflammatory machinery that are associated with a 5-fold increased risk of developing colon cancer. The expression and the role of BTL in the gastrointestinal tract in normal and pathological condition, as well as its role as anthocyanins transporter in colon cancer cells will be take into account in Trans2care project.
EUT Edizioni Università di Trieste
Jovana Čvorović, Federica Tramer, Bilitranslocase and anthocyanins role in the gastrointestinal tract, in Sabina Passamonti (ed.), The Partners and the Objectives of Trans2Care, an Italy-Slovenia cross-border network of science and healthcare institutions, EUT - Edizioni Università di Trieste, 2014, pp. 151-155