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Search for compounds able to modulate fof1 atp synthase in switching from life enzyme to cell death executor
Zancani, Marco
et al.
2014
Abstract
Mitochondria are the main site of energy power in eukaryotic cells. The enzyme FOF1 synthase is
responsible for ATP production driven by the transmembrane proton gradient. The maintenance of a very low
permeability of the inner mitochondrial membrane is crucial for this mechanism, since sudden opening of the
permeability transition pore (PTP) leads to matrix swelling and outer membrane rupture, with release of proapoptotic
factors. Recently, it has been suggested that dimers of ATP synthase in mammals could represent the
main component of the mitochondrial PTP, a feature modulated by calcium and involving the matrix protein
Cyclophilin D (CyPD). This study would help to develop new tools for the identification of plant secondary
metabolites, in particular flavonoids, able to modulate PTP and therefore acting on the programmed cell death
mediated by mitochondria. Therefore, this project would represent the first screening for plant molecules able
to interfere with programmed cell death, as a preliminary study for the development of drugs active in PTPrelated
pathologies.
Publisher
EUT Edizioni Università di Trieste
Source
Marco Zancani, Giovanna Lippe, Enrico Braidot, Elisa Petrussa, Valentino Casolo, Carlo Peresson, Sonia Patui, Alberto Bertolini, Valentina De Col, Paolo Bernardi, Angelo Vianello, Search for compounds able to modulate fof1 atp synthase in switching from life enzyme to cell death executor, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 261-265
Languages
en
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