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Novel markers for neurodegeneration
Barbisin, Maura
Vanni, Silvia
Legname, Giuseppe
2014
Abstract
Prion diseases are incurable and fatal neurodegenerative disorders that affect both humans and
animals. The causative agent is an infectious protein called prion (PrPSc), which is the pathological form of a
normal protein (PrPC) present on the cell membrane. The molecular mechanisms underlying prion replication
and subsequent degeneration of the Central Nervous System (CNS) are still poorly understood and therefore
innovative approaches are needed to build diagnostic, therapeutic, taxonomic, and disease surveillance tools.
We adopted an unbiased genomic approach and conducted whole transcriptome analyses using microarray
and RT-qPCR gene expression methods in brain of infected macaques versus healthy controls. We identified a
set of genes that could become novel biomarkers for early diagnosis and/or therapeutic strategies for prion
diseases and other neurodegenerative disorders.
Publisher
EUT Edizioni Università di Trieste
Source
Maura Barbisin, Silvia Vanni and Giuseppe Legname, Novel markers for neurodegeneration, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 141-145
Languages
en
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