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Krt14-expression as a marker of lung regeneration/repair
Amadio, Giulia
et al.
2014
Abstract
Currently, little is known about the cellular and molecular mechanisms that promote alveolar
epithelial repair. A recent study suggests that Keratin14-expression could represent a marker of alveolar
regeneration, since its expression was immunoistochemically detected in hyperplastic pneumocytes in human
samples of ARDS-related DAD. Here we shown the analysis on lung samples of various human diseases in
order to confirm the hyphotesis of the previous study. We used two molecular biology tecniques, Real Time Pcr
and Western Blot, on autoptical and bioptical lung specimens. As a result, we demonstrate here that Krt14-
expression is only found in pathological samples with alveolar regeneration or repair, while all normal control
samples are Krt14 negative.
Subjects
Publisher
EUT Edizioni Università di Trieste
Source
Giulia Amadio, Emanuele Buratti, Rossana Bussani, Marco Confalonieri, Krt14-expression as a marker of lung regeneration/repair, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 175-177
Languages
en
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