Options
Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance
De Leo, Luigina
Not, Tarcisio
2014
Abstract
Genetic gluten intolerance is a multifactorial condition characterized by the intestinal synthesis of
antitransglutaminase antibodies (anti-tTG) which might represent an early stage of this intolerance in absence
of both intestinal damage and serum anti-tTG. The double immunofluorescence staining (IF) is able to point
out these anti-tTG antibodies directly on intestinal biopsy. Her we describe a prospective study in which
patients were analysed for genetic predisposition (HLA DQ2-DQ8) and serum anti-tTG and were monitored
for clinical conditions and serum anti-tTG concentration during gluten free diet (GFD) or gluten containing diet
(GCD). Our results demonstrate that the measurement of intestinal anti-tTG is a useful screening procedure to
identify patients with genetic predisposition not fullfilling the current diagnostic criteria.
Publisher
EUT Edizioni Università di Trieste
Source
Luigina De Leo,Tarcisio Not, Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 153-156
Languages
en
File(s)