Exploring the biological properties and therapeutic potential of antimicrobial peptides

Abstract

The researchers involved in the Trans2Care project at the Department of Medical and Biological Sciences of the University of Udine investigate the biological properties of the antimicrobial peptides (AMPs) of the immune system and their therapeutic potential for human and veterinary application. In addition to potent and broad-spectrum antimicrobial activities, some AMPs display anti-inflammatory and immunomodulatory effects and hold promise as novel antiinfective agents combining antibiotic and immunostimulating properties. A detailed knowledge of their physicochemical, biological and pharmacological properties and of their impact on clinical settings is an important prerequisite to this end. The Trans2Care project offers an invaluable opportunity to share knowledge, technical expertise and laboratory facilities to achieve a better understanding of the biological features and therapeutic potential of AMPs.