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Title: Infrared micro-spectroscopy to distinguish glioma and glioma-stem cells
Authors: Kenig, Saša
et al.
Keywords: GLIOMAstem cellsglioblastomainfrared microspectroscopydifferentiation
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Saša Kenig, Diana Bedolla, Valentina Faoro, Alessandro Vindigni, Paola Storici, Lisa Vaccari, Infrared micro-spectroscopy to distinguish glioma and glioma-stem cells, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 107-110
In the last years the development of microfluidic devices enabled infrared micro-spectroscopy
(IRMS) to be applicable to biological samples. In the present study this method was used to find differences
between glioma cells and glioma stem cells. The ability of glioma stem cells to initiate new tumor formation
and their resistance to therapies makes these cells one of the main reasons why the most malignant form of
glioma – glioblastoma is at present incurable. Several classic markers of glioma stem cells have been reported
but none of them is their exclusive feature. Here we present preliminary results showing that by applying
principal component analysis to IRMS data we can separate glioma stem cells and non-stem cells into two
groups proving the potential of this technique. Further experiments are ongoing.
Type: Book Chapter
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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