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Title: Inhibitory effects of chitosan coating against biofilm formation on metal implants
Authors: Šulek, Franja
Milošev, Ingrid
Keywords: TRANS2CAREbacterial adhesionorthopedic metalschitosan coatingantibacterial
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Franja Šulek, Ingrid Milošev, Inhibitory effects of chitosan coating against biofilm formation on metal implants, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 133-138
Abstract: An effective approach to combat bacteria adhesion onto metallic implants surface is to functionalize the biomaterial surface such that bacterial growth could be impaired or the bacteria are killed upon contact with the surfaces. In the recent years, a majority of the research in material science has been devoted to modification or functionalization of implant surfaces with composite coatings with bactericidal capability such as polymeric coatings. For instance, chitosan (CH) is a polycationic polysaccharide which antibacterial properties and osteoblast function-enhancing nature has received substantial interest. The main goal of our study was to evaluate the effect of different chitosan-coated metals, routinely used in orthopaedics, on the survival of Staphylococcus epidermidis and Staphylococcus aureus. The results clearly showed that survival of attached bacteria onto metals functionalized with chitosan was lower when compared to bacterial survival determined on the surface of unmodified metals. Moreover, chitosan coating caused bacterial cells to lose their regular spherical shape. Thus, the results proved that chitosan could be used as alternative material for the preparation of antimicrobial coatings for implants.
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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