Please use this identifier to cite or link to this item:
http://hdl.handle.net/10077/10278
Title: | Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance | Authors: | De Leo, Luigina Not, Tarcisio |
Keywords: | TRANS2CARE; genetic gluten intolerance; antitransglutaminase antibodies; immunofluorescence | Issue Date: | 2014 | Publisher: | EUT Edizioni Università di Trieste | Source: | Luigina De Leo,Tarcisio Not, Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 153-156 | Abstract: | Genetic gluten intolerance is a multifactorial condition characterized by the intestinal synthesis of antitransglutaminase antibodies (anti-tTG) which might represent an early stage of this intolerance in absence of both intestinal damage and serum anti-tTG. The double immunofluorescence staining (IF) is able to point out these anti-tTG antibodies directly on intestinal biopsy. Her we describe a prospective study in which patients were analysed for genetic predisposition (HLA DQ2-DQ8) and serum anti-tTG and were monitored for clinical conditions and serum anti-tTG concentration during gluten free diet (GFD) or gluten containing diet (GCD). Our results demonstrate that the measurement of intestinal anti-tTG is a useful screening procedure to identify patients with genetic predisposition not fullfilling the current diagnostic criteria. |
Type: | Book Chapter | URI: | http://hdl.handle.net/10077/10278 | ISBN: | 978-88-8303-572-2 | eISBN: | 978-88-8303-573-9 |
Appears in Collections: | Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020? |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Luigina De Leo.pdf | 204.33 kB | Adobe PDF | ![]() View/Open |
CORE Recommender
Page view(s) 50
573
checked on Jan 30, 2023
Download(s) 50
560
checked on Jan 30, 2023
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License