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Title: Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance
Authors: De Leo, Luigina
Not, Tarcisio
Keywords: TRANS2CAREgenetic gluten intoleranceantitransglutaminase antibodiesimmunofluorescence
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Luigina De Leo,Tarcisio Not, Intestinal antitransglutaminase antibodies to discover genetic gluten intolerance, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 153-156
Genetic gluten intolerance is a multifactorial condition characterized by the intestinal synthesis of
antitransglutaminase antibodies (anti-tTG) which might represent an early stage of this intolerance in absence
of both intestinal damage and serum anti-tTG. The double immunofluorescence staining (IF) is able to point
out these anti-tTG antibodies directly on intestinal biopsy. Her we describe a prospective study in which
patients were analysed for genetic predisposition (HLA DQ2-DQ8) and serum anti-tTG and were monitored
for clinical conditions and serum anti-tTG concentration during gluten free diet (GFD) or gluten containing diet
(GCD). Our results demonstrate that the measurement of intestinal anti-tTG is a useful screening procedure to
identify patients with genetic predisposition not fullfilling the current diagnostic criteria.
Type: Book Chapter
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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