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Title: Krt14-expression as a marker of lung regeneration/repair
Authors: Amadio, Giulia
et al.
Keywords: LungregenerationrepairKeratin 14
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Giulia Amadio, Emanuele Buratti, Rossana Bussani, Marco Confalonieri, Krt14-expression as a marker of lung regeneration/repair, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 175-177
Abstract: Currently, little is known about the cellular and molecular mechanisms that promote alveolar epithelial repair. A recent study suggests that Keratin14-expression could represent a marker of alveolar regeneration, since its expression was immunoistochemically detected in hyperplastic pneumocytes in human samples of ARDS-related DAD. Here we shown the analysis on lung samples of various human diseases in order to confirm the hyphotesis of the previous study. We used two molecular biology tecniques, Real Time Pcr and Western Blot, on autoptical and bioptical lung specimens. As a result, we demonstrate here that Krt14- expression is only found in pathological samples with alveolar regeneration or repair, while all normal control samples are Krt14 negative.
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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