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Title: Metabolic bone disorders: from bench to bedside
Authors: Nicolin, Vanessa
De Iaco, Doriano
Valentini, Roberto
Keywords: TRANS2CAREbonedisorderosteoclastco-cultureRANKL
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Vanessa Nicolin, Doriano De Iaco, Roberto Valentini, Metabolic bone disorders: from bench to bedside, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 233-236
Bone is a complex tissue that have many function, when bone remodeling becomes perturbed
we can assist at many pathologies. The key factor in these pathologies is a perturbation of RANKL/RANK/OPG
pathways. We have tune up a 3D culture system that have the advantage to produce osteoclast cells more
physiological than the administration of the recombinant RANKL protein. This can be useful when study new
drugs to avoid the cross-reaction with the exogenous cytokines.
Type: Book Chapter
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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