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Title: The microtransplantation technique: a simple ad useful approach to study receptors transplanted into xenopus oocytes
Authors: Bernareggi, Annalisa
Sciancalepore, Marina
Lorenzon, Paola
Keywords: receptorsXenopus oocytesmicrotransplantationneurological diseasestwo-electrode voltage-clamp
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Annalisa Bernareggi, Marina Sciancalepore, Paola Lorenzon, The microtransplantation technique: a simple ad useful approach to study receptors transplanted into xenopus oocytes, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 271-274
Neuroreceptors are involved in many neurological diseases and represent the preferential target
for the pharmacological treatments. Thus functional studies of their activity, by the use of electrophysiological
techniques, are a fundament approach to understand not only the pathological mechanism of many
neurological diseases but also the mechanism of action of potential drugs. Unfortunately, this cannot be
applied for studying the receptor activity in all the human tissues. The option is the use of animal models,
however they often resemble only some of the neurological diseases in human. In addition, adult or old
animals are not always suitable for electrophysiological studies of age-related diseases. Here, we propose the
microtransplantation technique as a novel and useful method to study receptors in humans and, more in
general, in adult animals.
Type: Book Chapter
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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