X-ray diffraction @ elettra synchrotron: atomic insight of your biomedical target

Abstract

Crystallography is an invaluable tool to understand atomic structure. The knowledge at atomic scale of small and large molecules is crucial for many biomedical and biotechnological applications, ranging from drug design and optimization to enzyme functional studies and engineering. The physical properties of the solid state seen in crystals and powders of both drugs and pharmaceutical excipients are of interest because the nature of the crystalline form of a drug substance, due to polymorphism, may affect both the production and formulation as well as its stability in the solid state, its solution properties and its absorption. We offer a comprehensive access to state of the art X-ray diffraction tools and methodologies, supporting all the steps, from sample preparation to 3D structure analysis.