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Title: X-ray diffraction @ elettra synchrotron: atomic insight of your biomedical target
Authors: Bais, Giorgio
et al.
Keywords: X-Ray diffractionMacromolecular CrystallographyAlzheimer’s diseaseCK2 kinasedrug polymorphismXRD1Structure Based Drug DesignActive Pharmaceutical Ingredients
Issue Date: 2014
Publisher: EUT Edizioni Università di Trieste
Source: Giorgio Bais, Alberto Cassetta, Sonia Covaceuszach, Nicola Demitri, Doriano Lamba, Alessandro Pesaresi, Maurizio Polentarutti, X-ray diffraction @ elettra synchrotron: atomic insight of your biomedical target, in S. Passamonti, S. Gustincich, T. Lah Turnšek, B. Peterlin, R. Pišot, P. Storici (Eds.), Cross-border Italy-Slovenia biomedical research: are we ready for horizon 2020? Conference proceedings with an analysis of innovation management and knowledge transfer potential for a smart specialization strategy. Trieste, EUT Edizioni Università di Trieste, 2014, pp. 281-287
Crystallography is an invaluable tool to understand atomic structure. The knowledge at atomic
scale of small and large molecules is crucial for many biomedical and biotechnological applications, ranging
from drug design and optimization to enzyme functional studies and engineering. The physical properties of
the solid state seen in crystals and powders of both drugs and pharmaceutical excipients are of interest because
the nature of the crystalline form of a drug substance, due to polymorphism, may affect both the production
and formulation as well as its stability in the solid state, its solution properties and its absorption. We offer a
comprehensive access to state of the art X-ray diffraction tools and methodologies, supporting all the steps,
from sample preparation to 3D structure analysis.
Type: Book Chapter
ISBN: 978-88-8303-572-2
eISBN: 978-88-8303-573-9
Appears in Collections:Trans2Care, 2014. Cross-Border Italy-Slovenia Biomedical Research. Are we ready for Horizon 2020?

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