Please use this identifier to cite or link to this item:
Title: C1q is an active player in cancer microenvironment promoting tumour growth and invasion independently of complement activation
Authors: Rami, Damiano
Supervisore/Tutore: Bulla, Roberta
Agostinis, Chiara
Issue Date: 28-Apr-2015
Publisher: Università degli studi di Trieste
Abstract: It is now recognized that C1q can exert functions unrelated to C activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. We found that C1q-deficient (C1qa-/-) mice bearing a syngeneic B16 melanoma have a slower tumour growth and prolonged survival compared to wild-type (WT) or C3- or C5-deficient mice. This effect was not attributable to differences in the tumour infiltrating immune cells. Tumours developing in WT mice displayed early deposition of C1q, higher vascular density and increased number of lung metastases than those growing in C1qa-/- mice. Bone marrow chimeras between C1qa-/- and WT mice allowed the identification of non-bone marrow-derived cells as the main local source of C1q that can promote cancer cell adhesion, migration and proliferation. Together these findings strongly support a role for locally synthesized C1q in promoting tumour growth.
Ciclo di dottorato: XXVII Ciclo
Description: 2013/2014
Keywords: C1q
Complement system
Tumour microenvironment
Cancer-related inflammation
Bone-marrow transplantation
Language: en
Type: Doctoral Thesis
Settore scientifico-disciplinare: MED/04 PATOLOGIA GENERALE
NBN: urn:nbn:it:units-14041
Appears in Collections:Scienze biologiche

Files in This Item:
File Description SizeFormat
RAMI_phd.pdfTESI DI DOTTORATO5.64 MBAdobe PDFThumbnail
Show full item record

CORE Recommender

Page view(s)

checked on Apr 14, 2019


checked on Apr 14, 2019

Google ScholarTM


This item is licensed under a Creative Commons License Creative Commons