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Title: Studio randomizzato controllato vs placebo su efficacia e sicurezza della Talidomide nelle mici in pediatria: disegno, conduzione, risultati preliminari
Other Titles: Studio randomizzato controllato verso placebo
Authors: Lazzerini, Marzia
Keywords: Malattie Infiammatorie Croniche IntestinaliTalidomidePediatriaMorbo di CrohnRettocolite ulcerosa
Issue Date: 19-Jan-2009
Publisher: Università degli studi di Trieste
Abstract: Thalidomide is a small molecule with anti-TNF properties, recently emerged for the treatment of inflammatory bowel diseases (IBD) in adults and children. This is a report of the preliminary results of a multicenter double-blind vs placebo controlled trial to evaluate thalidomide efficacy and safety in inducing remission in untreatable patient with IBD aged 2-20 years. Patients non-responder to placebo are further treated with thalidomide open-label, and followed up for 52 weeks. Overall, thalidomide induced remission in 15/27 (55%) patients with CD and 7/10 (66%) patients with UC, compared to only one children in the placebo group (p=0.01, p=0.05). All 15 patients with CD and 6/7 pts with UC reaching remission with thalidomide are maintaining remission, with a mean follow up respectively of 58 weeks (range 12 to 104 weeks) and 52 weeks (range 26-78 weeks). Clinical and electromiographical sign of neuropathy occurred in 5/36 (13%), while persistent isolated electromiographical signs occurred in 3 more patient. There was one case of arterial cerebral thrombosis in a child with severe disease, for which thalidomide role is under discussion.
Description: 2007/2008
NBN: urn:nbn:it:units-7360
Appears in Collections:Scienze mediche

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Lazzerini-Dottorato.pdfLazzerini- File principale di tesi1.49 MBAdobe PDFView/Open
Lazzerini- Dottorato Bibliografia.pdfLazzerini- File con bibliografia tesi143.4 kBAdobe PDFView/Open
Lazzerini - Dorrorato ALLEGATO1.pdfLazzerini- ALLEGATO 1 alla tesi969.55 kBAdobe PDFView/Open
Lazzerini- Dottorato ALLEGATO 2.pdfLazzerini- ALLEGATO 2 alla tesi221.67 kBAdobe PDFView/Open
Lazzerini- DOttorato ALLEGATO 3.pdfLazzerini- ALLEGATO 3 alla tesi59.89 kBAdobe PDFView/Open
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