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Title: Detection of spirochaetal DNA simultaneously in skin biopsies, peripheral blood and urine from patients with erythema migrans
Authors: Pauluzzi, Paolo
Bonin, Serena
Gonzalez Inchaurraga, Maria Angeles
Stanta, Giorgio
Trevisan, Giusto
Keywords: erythema migranslyme borreliosisparaffin-embedded tissuespcr analysis
Issue Date: 2004
Publisher: Taylor & Francis
Source: Acta Derm Venereol 2004; 84: 106–110
Series/Report no.: Acta dermatologica venereologica
84(2004) issue 2(March)
Lyme borreliosis is an emerging zoonosis transmitted by infected hard-bodied ticks. The disease is multisystemic. In the initial stage its typical manifestation is the erythema migrans, a cutaneous lesion that occurs in up to 90% of patients. In order to investigate the presence of the specific agent, Borrelia burgdorferi, in the early stages of the disease, DNA from skin biopsies, urine and peripheral blood of 30 patients with clinically documented erythema migrans and without apparent systemic involvement was analysed by polymerase chain reaction. Borrelia DNA in both blood and skin biopsies was detected in 23 patients, while in 9 patients it was discovered in urine and skin biopsies. These results demonstrate that Borrelia DNA is detectable systemically also in patients with early Lyme borreliosis and strongly suggest a possible dissemination of the causative agents even when only a local infection is assumed.
Type: Article
ISSN: 0001-5555
DOI: 10.1080/00015550310006815
Appears in Collections:Scienze mediche

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