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Title: Peptides as Recognition and Sensing Elements
Other Titles: Peptidi: Elementi Attivi nel Riconoscimento Molecolare
Authors: Pavan, Silvia
Keywords: efavirenzdesigned peptidesmolecularly imprinted polymersminiaturized receptorsbiorecognitiontherapeutic drug monitoring
Issue Date: 23-Apr-2013
Publisher: Università degli studi di Trieste
Abstract: The project deals with the design and development of artificial receptors for monitoring of drugs used for the HIV “Anti-Retroviral Therapy” (ART). Efavirenz, a RT-inhibitor, and its analogues were synthesised to screen with several techniques (surface plasmon resonance, NMR, fluorescence and UV spectroscopy) the new receptors obtained from different approaches. One exploits computational tools to model peptides with high affinity for small molecules. These designed peptides will then be incorporated in polymeric matrix for biosensor purposes. Molecularly imprinted polymers with efavirenz-binding properties were performed during my experience at Queen Mary University of London. Another approach is based on miniaturized receptors obtained from the reduction of the known sequence of a natural receptor as human serum albumin.
Description: 2011/2012
NBN: urn:nbn:it:units-10077
Appears in Collections:Scienze chimiche

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